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TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells

Supplementary Table S1 provided the main characteristics of included clinical trial and case-report studies which investigated the effect of nutrient supplements on migraine

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The oxidative stress status was evaluated by quantifying the lipid peroxidation marker MDA and the antioxidant defense enzymes SOD and reduced GSH