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Whole-body cryotherapy chambers are available in major Canadian cities including Toronto, Vancouver, Calgary, Montreal, and Ottawa

3h, i of mice treated with 100 nmol kg 1 MK-801 ( n = 8 mice and n = 4 cages), 100 nmol kg 1 GLP-1 ( n = 8 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice and n = 4 cages) or vehicle (isotonic saline, n = 8 mice and n = 4 cages) for 5 days

doi: 10.1038/s41392-023-01673-4 192 PeiselerMSchwabeRHampeJKubesPHeikenwlderMTackeF

GLP-1 drugs dampens the dopamine reward loop so users dont get the same emotional payoff from drinking, explained Ellis

High out-of-pocket costs have led to modified usage, including alternate-week dosing in semi-urban belts