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Christensen et al., reported a KRAS G12C inhibitor that demonstrated pronounced tumor regression in multiple KRAS -mutant tumor models (148)

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Despite this, they did not investigate how hypocarnitinemia impacted the efficacy of diet therapy

Inhibition of protein translation restored both mTORC1 signaling and the ISR during cystine starvation, suggesting the bulk of cellular cysteine was committed to the biosynthetic process

Patients should choose a timing approach that best supports their adherence and tolerability preferences