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Multiple groups comparation were carried out via one-way analysis of variance with two-stage linear step-up procedure of Benjamini, Krieger and Yekutieli

Cells were passaged when they reached 7080% confluence, again maintaining 30 10 6 cells at each serial passage, with 5FU added in fresh media every 3 days

Carnitine can help the heart adapt to the disease environment via metabolic reprogramming by regulating changes in oxidative metabolism, glycolysis and ATP production in the damaged myocardium [287]

LC-MS 2 analysis The LC was performed on a fully automated EASY-nLC 1200 (Thermo Scientific)