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In Phase 3 TRIUMPH-4 trials, 33% of participants at the 12 mg dose experienced diarrhea compared to 13.4% on placebo

References Hunter DJ, Bierma-Zeinstra S

While NSAIDs and other lifestyle factors can contribute to glutathione depletion, proactive strategiesincluding diet, exercise, and stress managementcan help support the bodys natural antioxidant defenses

Allergy 76 (11), 34333445

We also consider the effect of these molecules on other obesity-related complications [glycaemia in people with T2D and on liver fat content in people with MASLD/metabolic dysfunction-associated steatohepatitis (MASH, previously known as non-alcoholic steatohepatitis)] and we discuss the potential clinical implications and challenges that the new era in obesity pharmacotherapy will bring