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To harness the protein-degradation activity of this HSP90 chaperone complex, we developed a novel targeted protein degradation technology, termed Chaperone-Mediated Protein Degradation (CHAMP), and an ERK5-CHAMP was designed to induce chemical proximity between HSP90 and ERK5 to induce ERK5 degradation

Gutierrez-RepisoCMolina-VegaMBernal-LopezMRGarrido-SanchezLGarcia-AlmeidaJMSajouxIet al

Risk factors for amyotrophic lateral sclerosis

Cellular Turnover and Pigmentation One of the less-publicized but clinically notable effects of GHK-Cu is its influence on cellular turnover rate

these covariates did not impact the models and therefore were not included in the following results