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As the disease progresses, the abnormal synovium invades surrounding tissues, and produces chemical substances that destroy the cartilage and bone of the joint surface

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A 2022 meta-analysis evaluating multiple stem cell trials found that: Childhood Autism Rating Scale (CARS) scores were significantly lower in stem cell groups compared to control groups Improvements were observed in behavioral assessments and adaptive functioning Another study involving umbilical cord mesenchymal stem cells reported improvements in behavioral scores over a nine-month follow-up period