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Secretion of IL-6, TNF-, IL-8, CCL2, and MMP-9 is significantly upregulated in AMs following EVC challenge

When possible, the pooled RRs were separately estimated for cancer incidence and mortality

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It increases dopamine and norepinephrine production in the brain

10.1186/s13065-023-00918-1 Summary Keywords nicotine pouches, oral cancer, oral health, smokeless tobacco, smoking Citation La Rosa GRM, Samaranayake LP, Zaura E, Chapple I and Polosa R (2026) Nicotine pouches, oral cancer and tobacco harm reduction: current evidence and research priorities