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Parkinsons disease PD is characterized by a gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of intracellular aggregates of misfolded -synuclein that causes motor dysfunction [124]

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Stampfer et al, 1992), some prospective studies did not find a statistically significant association between elevated homocysteine levels and the incidence of cardiovascular disease, after adjustment for conventional risk factors (Alfthan et al, 1994

Vitamins and Parkinsons disease In PD, Vit D deficiency has been shown to contribute, not only to the reduction in dopamine levels, but may also be involved in the accumulation of alpha-synuclein (SN), a hallmark of PD pathophysiology (Zhou et al