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By modifying the OXM peptide sequence with an amino acid-peptide substitution at position 2 to prevent DPP-4 action, in addition to a cholesterol-peptide conjugate, Pocai and colleagues were the first group to show that synthetic dual-agonists were an effective treatment strategy in an animal model

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Lu AT, Seeboth A, Tsai P-C, et al

These systems illustrate how biologically validated peptides can be reassessed using modern pharmacologic principles to uncover therapeutic opportunities previously obscured