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These catechol estrogen metabolites can be further changed by the COMT (catechol-O-methyltransferase) enzyme or through glucuronidation ( UGT genes)

How GLP-1 Medicines Work in the Body and Brain These medicines slow digestion, regulate blood sugar, and interact with brain regions involved in appetite

These may include nutritional counseling, exercise programs, behavioral support and FDA-approved medications like GLP-1 injections or the Wegovy pill