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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Abassi Z., Higazi A.A.R., Kinaneh S., Armaly Z., Skorecki K., Heyman S.N

Unstable iron (mainly in the form of ferrous iron) can react with oxygen and produce ROS, such as hydroxyl radicals and hydrogen peroxide, which are related to lipid peroxidation and tissue damage induced through the Fenton reaction

Albano E, Rundgren M, Harvison PJ, Nelson SD, Moldus P

These cohorts serve as compelling examples of the lack of direct GH counter-regulatory effects on pancreatic -cell insulin secretion, thus implying that circulating insulin exerts its glucose-lowering effects more efficiently in these subjects compared with healthy controls

Furthermore, there has been an indication of tirzepatide reducing liver fat, and improving nephrotic outcomes as evidenced by the lower urine albumin: creatinine ratio and the slower decline of estimated glomerular filtration rate in people with T2DM [56]