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Author Contributions Z.X., M.M., K.Hi., and J.S

PT-141 is also metabolised by peptidases, but its cyclic structure makes it more resistant to enzymatic degradation than linear peptides, which is why subcutaneous bioavailability exceeds 80%

Alcohol use disorder affects around 10% of adults in the United States, yet only 2% receive medications approved for AUD (MAUD), and among those who do, medication adherence is often poor

Sensitivity Analysis: Requirement for at Least Two Prescriptions for Baseline GLP-1 RA Prescription data reflect which medications are prescribed, but such prescriptions are not always collected and then used by the individual

[11] For the sermorelin-tirzepatide combination, there is no established clinical scenario that would meet these criteria, as evidence-based, licensed alternatives exist for both weight management and metabolic health optimisation