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The level of extracellular glutamate is determined by three factors: (1) vesicular-released glutamate at the synapses, (2) non-vesicular-released glutamate from the system xc() (see above) [71], and (3) glutamate uptake by EAATs on astrocytes [72]

Furthermore, heritability estimates range from 30 to 40% (Girgenti et al., 2021) with genome-wide studies implicating immune-linked loci such as ANKRD55 among others (Stein et al., 2016

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J Pharmacol Exp Ther 301: 820829, 2002