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Interestingly, losartan, a commonly used hypertension medication that acts on the angiotensin II receptor, reduced the receptor activity down to the same levels as the control.[ref] Another recent study showed that patients with POTS were likely to have autoimmune activity towards the adrenergic receptors ( 1 receptor, 2 receptor, cholinergic, and opioid receptor-like 1).[ref] The 1 and 2 adrenergic receptors are activated by epinephrine and norepinephrine, tying back to the norepinephrine disruption of the autonomic nervous system.[ref] However, not everyone with POTS has autoimmune activity that interacts with the angiotensin receptors or the adrenergic receptors

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This would be a true out & back from the start point, and I wanted to give it a good effort, as I'm in the midst of training for a 24 hour race

Perry C