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Prolozone therapy is extremely safe and can be used to help resolve chronic pain

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8 Low uptake has been attributed to several factors, including only modest additional weight loss with the available therapies, safety concerns, lack of health-care professional experience with such therapies, and expectations that overweight/obesity should be managed with behavioral measures

However, in ApoE-deficient mice, sesamol did not produce a statistically significant increase in claudin-1 expression, suggesting that the protective effects of sesamol on gut barrier function are partially dependent on the presence of ApoE