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(3)Mediators: Three serum sex hormone traits (total testosterone, bioavailable testosterone, and sex hormone-binding globulin) from IEU Open GWAS and Peripheral immune cell statistics (GWAS Catalog accession codes: GCST0001391GCST0002121), including relative cell counts ( n = 192), morphological parameters ( n = 32), absolute counts ( n = 118), and median fluorescence intensity of surface antigens ( n = 389).In addition, transcriptomic Data, including, SLE from GEO dataset GSE72326 and PCa from The Cancer Genome Atlas (TCGA