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In overweight or obese patients without diabetes mellitus, patients treated with GLP-1 RAs had significantly reduced major adverse cardiovascular events, all-cause death, myocardial infarction, and revascularization when compared with placebo [36] [37] [38]

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The signal that targeting amylin could preserve lean mass during weight loss a key question about GLP-1 drugs has so far been from animal studies, Drucker pointed out, leading him to question whether that result would bear out in human studies