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The primary defect is missense mutation in the HFE gene resulting in a cysteine to tyrosine substitution at aminoacidic 282 (C282Y), a protein that interacts with transferrin receptor 1 (TfR1) and regulates the expression of hepcidin, a key regulator of iron metabolism represented in Diagram B of Figure 2

For example, ingested BPA alters behavior in rodents 32,33 and zebrafish larvae embryonically exposed to BPA are hyperactive 34,35 with multiple adverse neurobiological effects

Glutathione helps buffer that stress

Zhang C, et al