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Cysteine and homocysteine are GPX4 substrates This pathway is GSH-independent, with GPX4 showing a significantly higher affinity for cysteine and homocysteine than for GSH in the absence of GSH synthetase 114 , suggesting that these two pathways may form a new cellular antioxidant pathway

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Several decisions were close, and the committee heard substantial disagreement about chemical characterization, peptide-related impurities, immunogenicity, carcinogenicity signals or uncertainty, the limited quantity and quality of human evidence, and whether existing FDA-approved therapies already address the proposed uses

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Tirzepatide suffers the same problem but to a lesser extent