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Despite the many advances in SC-islet differentiation, these protocols produce a relatively lower frequency of insulin + -like cells that are not fully functional in vitro and have limited glucose-stimulated insulin secretion (GSIS) compared to cells within primary human islets

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Effect of pasteurized Akkermansia muciniphila MucT on insulin sensitivity, body composition, and GLP-1 production in subjects with metabolic syndrome Gut Microbes 2026;18(1):2690689 doi:10.1080/19490976.2026.2690689 (Human trial) Written by Ali Rza Akn Microbiome Scientist, Author & Founder of Next-Microbiome Ali Rza Akn is a microbiome scientist with nearly 30 years of experience in translational biotechnology, systems biology, and applied microbiome research, spanning discovery, preclinical development, and clinical-stage translation