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Flavonoids can alleviate neuroinflammatory processes and decrease the progression of neurodegenerative diseases through their regulatory effects on immune cells, particularly microglia (248)

B-cell Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) are critical cytokines responsible for B-cell survival and differentiation, and their overexpression in SLE supports proliferation of autoreactive B cells (140, 141)

However, it declines with age, so adding a supplement can help support the processes, even as production drops off

Its overall effect is likely influenced by multiple factors, including cellular iron buffering capacity, mitochondrial function, and antioxidant homeostasis

Smriti Choudhary, M.D