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The safety considerations outweigh any perceived convenience or cost savings

Curr Opin Toxicol 1:134138

These include a relative or absolute increase in glucagon secretion from alpha cells of the pancreas, elevated serum free fatty-acid concentrations, an impaired incretin effect (e.g., decreased secretion of glucagon-like peptide-1 [GLP-1]), enhanced renal reabsorption of glucose, and dysregulation of appetite control via decreased neurotransmitter response in the brain

Lund A, Knop FK, Vilsbll T

These techniques are rooted in physiological principles and can be remarkably effective in restoring a normal heart rhythm