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Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons

Cigarette control remains the priority as does the de-normalization of cigarettes/combustibles The arguments for controlling tobacco/nicotine products should not be uniform across all products, because the risks are not uniform, but dramatically different

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None of the products have received FDA authorization and they come in flavors like cotton candy, which regulators say can appeal to teenagers