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Furthermore, Vitamin C is a potent antioxidant that can be used to treat and prevent changes associated with photoaging

Its primary function is to transport long-chain fatty acids into the mitochondria, where they are burned to produce energy

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Mori MP, Penjweini R, Knutson JR, Wang PY, Hwang PM

Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH

doi: 10.1016/S2213-8587(21)00113-3