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Berberine: a review of its pharmacokinetics properties and therapeutic potentials in diverse vascular diseases

& Shimada, S

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Over 29 days of treatment, the peptide inhibited pulmonary artery muscularization (the thickening and stiffening of pulmonary arteries that drives this condition), prevented right heart hypertrophy (the enlargement of the right ventricle that occurs when it has to pump against increased resistance), and significantly decreased mortality