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Angioedema, a potentially serious allergic reaction involving deeper tissue swelling, has been documented in post-marketing reports, though it remains uncommon

While individual results vary, before and after changes in the skin, body, and face are among the most commonly reported outcomes

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People Taking Orforglipron Saw Substantial Reductions in Weight and A1C Levels In a 40-week placebo-controlled trial, people with type 2 diabetes taking the highest dose of orforglipron lost 16 pounds on average, or about 7.9 percent of their body weight, and were still losing weight when the study ended