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This breadth is both the compound's strongest argument and a source of appropriate scientific skepticism: a compound that seems to fix everything tends to invite scrutiny about study quality and publication bias

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Theres yet to be a firmly established causation between vitamin B-12 deficiency and depression, but there is growing evidence that low B-12 levels may contribute to depressive symptoms, especially in older adults or those with other risk factors

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Crane implies that haptocorrin can bind B12 in the mouth, but I wasnt able to verify this