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We noted that the lung to body weight ratio was indeed elevated in AA-exposed mice compared to PBS and melatonin-only controls, however the extent of this increase was substantially reduced in those mice which received melatonin alongside AA ( Figure 1B )

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Furthermore, many researchers have found that reduced GSH levels and GSH-dependent antioxidant enzyme activity in damaged myocardium due to excess ROS and disruption of the GSH synthesis process, along with increased oxidative damage and ferroptosis

Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: an in vivo study