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In another trial, 70 individuals with recurrent calcium kidney stones, high urine calcium concentration, and bone loss were treated with either 70 mg per week of alendronate or 70 mg per week of alendronate plus 50 mg per day of the diuretic hydrochlorothiazide

What we saw is that it takes people a lot of time to build cardiovascular protection and half the time to undo it, he says

These include nausea, vomiting, diarrhea and constipation

This sustained sensitivity may explain why some individuals report consistent benefits from low doses maintained over many months

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