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Things that might cause minor sores include: Stress Tissue injury, like from a sharp tooth or a dental appliance Certain foods, including citrus or acidic fruits and vegetables (such as lemons, oranges, pineapples, apples, figs, tomatoes, and strawberries) Nonsteroidal anti-inflammatory drugs like ibuprofen An allergy to something in your food, toothpaste, or mouthwash Helicobacter pylori , the bacteria that can cause peptic ulcers Things that might cause complex canker sores include: A health condition like a weakened immune system, HIV, AIDS, lupus, or Behcets disease Nutritional problems like too little vitamin B12, zinc, folic acid, or iron Gut diseases like celiac or Crohns About 1 in 5 people get canker sores regularly