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A 2026 review in the American Journal of Sports Medicine emphasizes that despite popularity, "significant research regarding the safety and efficacy of these therapeutic methods is required before definitive recommendations can be made to patients." Only a single human case series exists for BPC-157 (for knee pain), with significant methodological flaws and no controls

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Some patients with favorable genetic profiles tolerate the first injection with minimal side effects, while others experience more pronounced symptoms that resolve quickly as their body adapts

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Severe kidney disease or dehydration risk GI side effects can lead to dehydration and, in vulnerable patients, acute kidney injury