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Luz, C., Calpe, J., Saladino, F., Luciano, F.B., Fernandez-Franzon, M., Manes, J., et al., J

Conclusion Over the past years, GLP-1 antagonists have become a game-changer in weight management, offering a powerful tool for those struggling with obesity or Type 2 diabetes

Presented by Joo-Yong Hahn

Glucagon receptor agonism increases basal energy expenditure through stimulation of hepatic thermogenesis and fatty-acid turnover, and activates mitochondrial beta-oxidation

Glucagon-receptor activity is associated with increased energy expenditure and reduced liver fat, which is the mechanistic rationale for why retatrutide produced larger weight-loss figures in early trials