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While neither liraglutide nor semaglutide is FDA-approved for cardiovascular protection, research suggests both may help lower the risk of major heart-related events like heart attack, stroke, or cardiovascular death in people with type 2 diabetes
In SURPASS-2, a head-to-head diabetes trial, tirzepatide produced greater weight loss than semaglutide but that trial compared tirzepatide against semaglutide 1 mg, the diabetes dose, not the 2.4 mg dose used for weight management (Fras et al., 2021
Serious hypersensitivity reactions including anaphylaxis and angioedema have been reported with RYBELSUS Warnings and Precautions Risk of Thyroid C-Cell Tumors: Patients should be further evaluated if serum calcitonin is measured and found to be elevated or thyroid nodules are noted on physical examination or neck imaging Acute Pancreatitis: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including RYBELSUS
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Anesthesiologists Role The anesthesiologist evaluates aspiration risk and plans airway management accordingly
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