Pharmacology and Hepatotoxicity APAP absorption occurs rapidly in the duodenum, owing to its property as a weak acid.8 If a patient consumes food around the same time of APAP ingestion, there may be a delay in the time of, but not the extent of, drug absorption.8 Much like concurrent food consumption causing time-delay in APAP absorption, a patient with chronic liver disease is at risk of prolonged drug serum half-life (by an average of 2.0 to 2.5 hours, and up to more than 4 hours), especially if extended-release APAP formulations are consumed
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Before starting a patient on a GLP-1 medication, I emphasize that these are long-term medications to treat the chronic disease of obesity and prevent future complications
4 PfefferMAClaggettBDiazRDicksteinKGersteinHCKberLVet al
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