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In comparison to the intense DHE-positive staining observed in the aortic root sections of PBS-treated mice, obvious reductions in ROS-positive areas were noted following treatment with Mn/TI@mHSA, P-Mn@mHSA, or P-Mn/TI@mHSA-N

Of the other sites we propose, some are more likely than others, but those in TXNRD1 and SELENOF are particularly convincing, and all of the predicted sites map to surface accessible regions of the targeted proteins (Figure S3)

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Consistent with this effect we report here the induction of -GCS-HS, the catalytic subunit of the rate limiting enzyme in GSH biosynthesis which determines a greater GSH biosynthetic capacity of mucosa 7 days after TNBS treatment