Consequently, BDNF peaks correspond to greater relapse risk, and BDNF injections in specific brain regions in mice can modulate cocaine-seeking behaviors [32, 33]
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Before beginning therapy, lab tests are often performed to assess heavy metal levels, kidney function, and mineral status
However, the subsequent secondary injury arising minutes to months after the initial insult exacerbates the neuropathology through various cellular processes, including neuroinflammation, oxidative stress, metabolic dysfunction, and excitotoxicity (Walker and Tesco, 2013)