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Orforglipron (46 trials, 23 in Phase 3) may capture patients who prefer oral over injectable therapy

Patients that maintained treatment response for 2 weeks at the end of the open label treatment period were eligible to be randomized to ongoing treatment with the same dose of VYVANSE (N=78) or switched to placebo (N=79) during the double-blind phase

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Cases were only included in the analysis if toxicology reports showed the presence of opioids, with or without stimulants and other drugs

Immunoblotting was performed with 10 g of cytoplasmic and mitochondrial-enriched lysate as per the immunoblotting methods described below relative to whole-cell lysates