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The transcriptional regulation of these cytoprotective genes is tightly controlled by cis -acting elements, known as antioxidant response elements (ARE), present in the enhancer region 12

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The most common side effects of semaglutide include nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, heartburn and gastroparesis or stomach paralysis